| Week 1 | San Francisco 49ers vs. Los Angeles Rams | Thursday, September 10th, 2026 at 8:35pm ET |
| Week 2 | Miami Dolphins vs. San Francisco 49ers | Sunday, September 20th, 2026 at 4:25pm ET |
| Week 3 | Arizona Cardinals vs. San Francisco 49ers | Sunday, September 27th, 2026 at 4:05pm ET |
| Week 4 | Denver Broncos vs. San Francisco 49ers | Sunday, October 4th, 2026 at 4:25pm ET |
| Week 5 | San Francisco 49ers vs. Seattle Seahawks | Sunday, October 11th, 2026 at 4:25pm ET |
| Week 6 | Washington Commanders vs. San Francisco 49ers | Monday, October 19th, 2026 at 8:15pm ET |
| Week 7 | San Francisco 49ers vs. Atlanta Falcons | Sunday, October 25th, 2026 at 1:00pm ET |
| Week 8 | Bye Week | |
| Week 9 | Las Vegas Raiders vs. San Francisco 49ers | Sunday, November 8th, 2026 at 4:05pm ET |
| Week 10 | San Francisco 49ers vs. Dallas Cowboys | Sunday, November 15th, 2026 at 4:25pm ET |
| Week 11 | Minnesota Vikings vs. San Francisco 49ers | Sunday, November 22nd, 2026 at 8:20pm ET |
| Week 12 | Seattle Seahawks vs. San Francisco 49ers | Sunday, November 29th, 2026 at 4:25pm ET |
| Week 13 | San Francisco 49ers vs. New York Giants | Sunday, December 6th, 2026 at 1:00pm ET |
| Week 14 | Los Angeles Rams vs. San Francisco 49ers | Sunday, December 13th, 2026 at 4:25pm ET |
| Week 15 | San Francisco 49ers vs. Los Angeles Chargers | Thursday, December 17th, 2026 at 8:15pm ET |
| Week 16 | San Francisco 49ers vs. Kansas City Chiefs | Sunday, December 27th, 2026 at 4:25pm ET |
| Week 17 | Philadelphia Eagles vs. San Francisco 49ers | Sunday, January 3rd, 2027 at 8:20pm ET |
| Week 18 | San Francisco 49ers vs. Arizona Cardinals | Sunday, January 10th, 2027 at 1:00pm ET |
