Wednesday’s MLB DFS main slates at DraftKings and FanDuel start at 6:35 p.m. ET. DraftKings’ slate has seven games, while FanDuel’s has eight, including the Royals at the Athletics contest. The Underdog pick’em selections are also from the night’s games. Let’s dive into today’s MLB DFS picks.
Wednesday’s Top MLB DFS Picks & Player Props
Wednesday’s Starting Pitcher Rankings (4/29)
Wednesday’s MLB DFS main slates at DraftKings and FanDuel start at 6:35 p.m. ET. DraftKings’ slate has seven games, while FanDuel’s has eight, including the Royals at the Athletics contest. The Underdog pick’em selections are also from the night’s games. Let’s dive into today’s MLB DFS picks.
Wednesday’s Top MLB DFS Picks & Player Props
Wednesday’s Starting Pitcher Rankings (4/29)
Cristopher Sanchez is an unstoppable force at home. According to FanGraphs, in 121 innings at home since last season, Sanchez has recorded a 1.79 ERA, 2.39 xFIP, 0.97 WHIP, 5.3% walk rate, 31.1% strikeout rate and 59.3% groundball rate.
Sanchez’s excellence at home complements San Francisco’s mediocre road numbers. The Giants are 13th in wRC+ (97) with a 20.4% strikeout rate on the road. Additionally, Sanchez’s betting info is rock-solid. The Phillies are -140 favorites, and the game’s total is a pitcher-friendly seven runs.
Tarik Skubal hasn’t pitched at an otherworldly level this year, but he’s still pitched like an ace. In six starts spanning 36.1 innings in 2026, Skubal has put up the following stats.
- 3 wins
- 4 quality starts
- 2.72 ERA
- 3.03 xERA
- 2.77 xFIP
- 3.00 SIERA
- 0.99 WHIP
- 4.2% walk rate
- 26.8% strikeout rate
- 13.6% SwStr%
- 29.1% CSW%
- 116 stuff+
- 107 location+
- 121 pitching+
Skubal’s matchup isn’t a cupcake. Nevertheless, his betting info is favorable. The Tigers are -144 favorites, and the game’s total is eight runs.
Gamers shouldn’t venture beyond Cristopher Sanchez and Tarik Skubal at FanDuel, and locating a palatable SP2 option at DraftKings wasn’t fun. The pitchers beyond the two lefty aces are flawed. So, why not save salary on an undesirable SP2?
Tomoyuki Sugano has a cheap salary. He also has a tasty matchup. The Reds are 27th in wRC+ (85) with a 24.6% strikeout rate versus righties and 21st in wRC+ (96) with a 26.1% strikeout rate at home this season. Sugano’s 3.42 ERA in five starts spanning 26.1 innings this season is a fluke, but the Reds are bad enough that they could allow him to avoid regression for at least one more start.
Suggested Lineup Stacks
JR Ritchie is making only his second start in the Majors after holding the Nationals to two runs on five hits (two homers) and two walks, with seven strikeouts. Ritchie had a 2.38 ERA in 16 career Triple-A starts. However, Ritchie’s 4.01 FIP was less flattering, and his 11.4% walk rate was unimpressive.
The Tigers have some firepower to make Ritchie’s second start in The Show a miserable one. Seven of Detroit’s projected starters have a 117 wRC+ or better against righties this season as of Tuesday night. The Tigers are also an affordable stack, which is critical because of Sanchez’s and Skubal’s salaries.
Logan Webb isn’t having a banner campaign — 4.86 ERA and 4.43 xERA in six starts.
On a weak pitching slate beyond the two lefty aces, Webb might soak up more interest from DFS gamers than he should, making for a compelling case to get leverage in GPPs by stacking the Phillies. Philadelphia has a blend of high-end talent and some bargain-salary options.
Core Studs
- Kevin McGonigle has rattled off 22 runs, two home runs, 12 RBI, two stolen bases, .417 on-base percentage (OBP), .191 ISO, .413 wOBA and 161 wRC+ in 127 plate appearances this season.
- Riley Greene has hit 52 homers with a .350 OBP, .245 ISO, .372 wOBA and 142 wRC+ in 975 plate appearances against righties since 2024.
- Bryce Harper is obscenely good with the platoon advantage at home. In 400 plate appearances against righties at home since 2024, Harper has hit 25 homers with a .405 OBP, .296 ISO, .422 wOBA and 171 wRC+.
Value Plays/Punts
- Brandon Marsh has amassed 12 runs, four homers, 17 RBI, three stolen bases, a .320 OBP, .170 ISO, .343 wOBA and 115 wRC+ in 100 plate appearances this season.
- Gary Sanchez has mashed 10 taters with a .324 OBP, .220 ISO, .341 wOBA and 119 wRC+ in 182 plate appearances against lefties since 2024.
- Colt Keith has drilled 25 dingers with a .326 OBP, 145 ISO, .320 wOBA and 106 wRC+ in 973 plate appearances against righties since 2024.
Wednesday’s Top 3 Underdog Player Props
Check out our best picks on the MLB Underdog Cheat Sheet 
Yordan Alvarez has tallied 39 hits (19 singles, nine doubles and 11 homers), a .355 batting average, .736 slugging rate and .382 ISO in 30 games and 134 plate appearances this season. He’s surpassed 1.5 total bases in seven of his last 10 games.
Gunnar Henderson has tallied 26 hits, 21 runs, 18 RBI, a .213 batting average, .287 OBP, .279 ISO, .337 wOBA and 112 wRC+ in 29 games and 136 plate appearances in 2026.
The left-handed-hitting shortstop is outstanding at home with the platoon advantage, recording 147 hits, a .306 batting average, .367 OBP, .268 ISO, .398 wOBA and 164 wRC+ in 529 plate appearances against righties at home since 2024.
Bryce Harper (1B – PHI): 1.5 Hits + Runs + RBIs — Higher (0.84x Payout)
Bryce Harper has logged 29 hits, 16 runs, 19 RBI, a .269 batting average, .350 OBP, .241 ISO, .375 wOBA and 136 wRC+ in 29 games and 123 plate appearances this season. He’s cleared a combined 1.5 hits + runs + RBIs in four of his last five games.
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Josh Shepardson is a featured writer at FantasyPros. For more from Josh, check out his archive and follow him @BChad50.
