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Isaac Guerendo

RB - San Francisco 49ers

  • 6'
  • 221 lbs
  • Age 26
  • Louisville
Rostered In ~0.5% of leagues

2026 Outlook

Strength of Schedule
RB Rank: 25th (hard)
Draft Rank (ECR)
#308
Best / Worst
#242 / #325
ADP
N/A

Availability



Isaac Guerendo (torn pec) to miss most of training camp

49ers head coach Kyle Shanahan announced Isaac Guerendo tore his pec while lifting weights a month ago and will miss the majority of training camp.

Fantasy Impact

Shanahan said that Guerendo "could" be ready by the end of training camp, but that was as specific a timeline as he provided. Guerendo will head into the season vying for the primary backup role behind Christian McCaffrey.

Diego Sandoval5 weeks ago
Isaac Guerendo (shoulder) will play Sunday

Isaac Guerendo (shoulder) will play in Sunday's game against the Seattle Seahawks.

Fantasy Impact

The young running back was able to practice fully all week despite being listed on the injury report with a shoulder issue. He will be good to go for Week 1 and will be primed for an increase in touches if Christian McCaffrey (calf) is ruled out ahead of game time for the 49ers.

Leo Sells42 weeks ago
Isaac Guerendo (shoulder) full participant Wednesday

Isaac Guerendo (shoulder) was a full participant at practice on Wednesday.

Fantasy Impact

Guerendo's status has been a little bit unclear over the past few weeks thanks to his shoulder injury, but he was a full participant at practice on Wednesday and should be available to play against the Seahawks on Sunday. He is not expected to have a strong role with Brian Robinson Jr. recently being acquired by the team, however.

Leo Sells43 weeks ago
Isaac Guerendo (shoulder) to miss a few weeks

Isaac Guerendo is expected to miss the next few weeks with a shoulder injury

Fantasy Impact

Guerendo got banged up over the weekend. He is expected to be competing with rookie Jordan James behind Christian McCaffrey in the 49ers backfield this season.

Ari Koslow47 weeks ago
Isaac Guerendo suffers apparent shoulder/arm injury Saturday

Isaac Guerendo left practice early on Saturday with an apparent right shoulder/arm injury.

Fantasy Impact

There should be an update on the status of Guerendo when available.

Ari Koslow47 weeks ago