Isaac Guerendo Fantasy Football Outlook (2025)

By Pat Fitzmaurice (FantasyPros), Sat, Aug 30th 2025, 12:53pm EDT

Isaac Guerendo was poised to be among the most valuable handcuff RBs in fantasy football this year as the presumed backup to the oft-injured Christian McCaffrey, who played only four games last year. But an Aug. 22 trade that brought ex-Commander Brian Robinson Jr. to San Francisco put Guerendo's role in doubt. Guerendo showed some intriguing flashes as a rookie. When he made his first two NFL starts in Weeks 14 and 15, he rolled up 203 yards from scrimmage and two touchdowns in those contests. But Guerendo now appears to have little redraft value for 2025.