San Francisco 49ers Fantasy Football Outlook (2025)

By Andrew Erickson (FantasyPros), Wed, Jul 9th 2025, 6:13pm EDT

The Niners have the easiest schedule in the NFL in 2025. Perks of finishing in fourth place in the NFC West, combined with matchups against the AFC South and NFC South.
And even though they open up the season with back-to-back road contests, it's at Seattle and New Orleans. Sam Darnold and Tyler Shough. Draft the 49ers D/ST that should have better health in 2025 under defensive coordinator Robert Saleh. Their DST ranks No. 1 in the FantasyPros strength of schedule tool.