Christian McCaffrey Week 1 Outlook - 49ers at Seahawks

By Ellis Johnson (FantasyPros), Sat, Sep 6th 2025, 7:34am EDT

He's baaaaaack! Not Kyle's cousin Kyle, but the legendary fantasy RB Christian McCaffrey is ready to regain his fantasy crown after missing almost all of last season. There are a few things worth forgetting, including the fact that Jaws had a sequel, and CMC's 2024 season is at the top of that list. If he is healthy (which remains TBD given the calf injury that has popped up late in the week), then CMC is a true X factor for fantasy. In 2023, CMC scored 357 fantasy points, which was 18 more than Barkley had last season. This season, the 49ers have one of the easiest schedules for running backs. Add that to the abundance of drama at the receiver position, and CMC should be fed both on the ground and through the air. Off pure usage, he could very well finish as the RB1 on the week against a revamped Seattle defense. But he can also become an injury headache. It seems like managers will need to embrace the risk as early as Week 1 with his questionable status.