Matthew Stafford Week 5 Outlook - 49ers at Rams

By Derek Brown (FantasyPros), Thu, Oct 2nd 2025, 1:05pm EDT

Matthew Stafford went legend mode last week as the QB2 in fantasy, which was his first QB1 outing of the season. Stafford is the QB17 in fantasy points per game. Among 38 qualifying quarterbacks, Stafford is crushing it, ranking fifth in yards per attempt, fourth in passing yards per game, third in passing touchdowns, and first in hero throw rate. Stafford should post strong QB2 numbers this week with the upside to sneak into the top 12 fantasy quarterbacks. The 49ers have allowed the 12th-highest passer rating while ranking 18th in CPOE and 16th in success rate per dropback.