George Kittle Week 10 Outlook - Rams at 49ers

By Ellis Johnson (FantasyPros), Wed, Nov 5th 2025, 6:27pm EST

Three weeks back from his hamstring injury, Kittle has been solid for fantasy. Although he has yet to show his true fantasy-breaking ability, it may only be a matter of time before he is firing on all cylinders. Unfortunately, this week they face the Rams, who are allowing the 10th fewest fantasy points to the position. However, after that, the 49ers only face one defense inside the 16 against TEs over their remaining seven games. If the 49ers want to beat a red-hot Rams team, Kittle may need to be at his best. Kittle is a must-play once again, and if he has another middling week, keep in mind a nice schedule down the stretch.