James Cook III Week 16 Outlook - Bills at Browns

By Ellis Johnson (FantasyPros), Mon, Dec 15th 2025, 5:44pm EST

For only the second time in his career, Cook graced us with a three-touchdown game to open up the fantasy playoffs. Despite New England being one of the toughest run defenses on the season, Cook tormented them for 107 yards and two scores on the ground, adding a third touchdown in the receiving game. This week, they face the Browns, who look like a terrible matchup on paper. However, since Week 10, the Browns are allowing the 14th fewest fantasy points to the RB position. Although not a phenomenal matchup, the Bills' offense against an average run defense should find a way to Cook (pun intended).