Christian McCaffrey Week 16 Outlook - 49ers at Colts

By Ellis Johnson (FantasyPros), Mon, Dec 15th 2025, 5:45pm EST

For the first time since Week 14 of 2023, CMC finished a game with only one target. Much like their match against the Titans last week, this was largely due to his ability to gouge the defence on the ground. Carrying the ball 22 times for 73 yards and a score was a surprisingly modest day at the office for the fantasy RB1. Unfortunately, his next two matchups are against solid run defenses, with the Colts and Bears, who are 11th and 13th in fewest RB fantasy points allowed since Week 10. Either way, CMC is not your average Joe. Whether it is through the air or on the ground, CMC will always find a way through for fantasy.