DeVonta Smith Week 17 Outlook - Eagles at Bills

By Derek Brown (FantasyPros), Sat, Dec 27th 2025, 9:35am EST

DeVonta Smith is the WR24 in fantasy points per game with a 24.2% target share, 62.1 receiving yards per game, 2.00 yards per route run, and a 30% first-read share. Smith is third on the team with ten red zone targets and first with 21 deep targets. This week, he faces a stout Buffalo secondary that, since Week 13, has had the second-highest two-high rate in the NFL (69.5%). Against two high, Smith leads the team with a 24.3% target share with 1.99 yards per route run (first on the team) and a team-leading 31.6% first-read share. Smith should lead the Philly passing attack this week and have success doing so. Since Week 12, Buffalo has allowed the fourth-most PPR points per target and the highest passer rating when targeted to slot receivers.