| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 10.6 | 16.1 | 29.9 | 34.4 | 16.1 | 25.2 | 24.7 | 14.2 | 25.8 | 13.6 | 21.1 | 210.6 | ||||||||
| 2 | Alvin Kamara | RB | NO | 19.5 | 43 | 14.2 | 21.4 | 9.6 | 14.9 | 5.4 | 15.2 | 24.5 | 13.4 | 18.1 | 181.1 | ||||||||
| 3 | Saquon Barkley | RB | PHI | 32.2 | 15.6 | 31.6 | 12.6 | BYE | 6.4 | 25.7 | 11.6 | 31.4 | 8.3 | 19.5 | 175.4 | ||||||||
| 4 | Bijan Robinson | RB | ATL | 13.6 | 14.2 | 12.2 | 9.4 | 9.2 | 24 | 21.8 | 20.1 | 18 | 27.9 | 17 | 170.4 | ||||||||
| 5 | Jahmyr Gibbs | RB | DET | 15.4 | 14.1 | 16.3 | 19.8 | BYE | 10.6 | 30 | 19.8 | 14.1 | 11.8 | 16.9 | 151.9 | ||||||||
| 6 | Kyren Williams | RB | LAR | 12.9 | 13.2 | 30.6 | 18.4 | 15 | BYE | 19.6 | 20.1 | 10 | 8.7 | 16.5 | 148.5 | ||||||||
| 7 | Chuba Hubbard | RB | CAR | 1.4 | 9.6 | 25.4 | 20.1 | 15.5 | 12.8 | 11.2 | 8.1 | 20.2 | 22.9 | 14.7 | 147.2 | ||||||||
| 8 | James Cook III | RB | BUF | 11.8 | 28 | 16.7 | 5.3 | 16.9 | - | 9.2 | 26.8 | 9.4 | 15 | 15.5 | 139.1 |