| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Alvin Kamara | RB | NO | 15.4 | 14 | 38.3 | 22.6 | 67.7 | |||||||||||||||
| 2 | Christian McCaffrey | RB | SF | 19.3 | 7.2 | 36.3 | 20.9 | 62.8 | |||||||||||||||
| 3 | Rhamondre Stevenson | RB | NE | 23.1 | 19.8 | 17.8 | 20.2 | 60.7 | |||||||||||||||
| 4 | Kenneth Walker III | RB | SEA | 18 | 28.7 | 11.7 | 19.5 | 58.4 | |||||||||||||||
| 5 | Travis Etienne Jr. | RB | JAC | 11.8 | 18.4 | 23.7 | 18 | 53.9 | |||||||||||||||
| 6 | Tony Pollard | RB | TEN | 6.2 | 11.9 | 33.2 | 17.1 | 51.3 | |||||||||||||||
| 7 | Derrick Henry | RB | BAL | - | 15.3 | 35.3 | 25.3 | 50.6 | |||||||||||||||
| 8 | Nick Chubb | RB | HOU | 7.5 | 17.7 | 24.9 | 16.7 | 50.1 |