| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 22.9 | 19.5 | 17.9 | 41.7 | 11.8 | 11.2 | 19.6 | 23.8 | BYE | 14.2 | 16.3 | 19.9 | 198.9 | |||||||
| 2 | Raheem Mostert | RB | LV | 11 | 24.7 | 38.2 | 2.5 | 13.8 | 31.2 | 5.1 | 10.6 | 14.5 | - | 9.3 | 16.1 | 160.9 | |||||||
| 3 | Travis Etienne Jr. | RB | JAC | 16.4 | 4.2 | 13.8 | 7.2 | 32.4 | 20.3 | 19.7 | 22.9 | BYE | 4.4 | 5.9 | 14.7 | 147.2 | |||||||
| 4 | Brian Robinson Jr. | RB | SF | 12.6 | 26.9 | 7 | 11.1 | 4.3 | 11.6 | 8.3 | 7.9 | 10.7 | 21.7 | 13.2 | 12.3 | 135.3 | |||||||
| 5 | Gus Edwards | RB | FA | 5.2 | 12.2 | 5.1 | 4.9 | 4.8 | 5.3 | 20.4 | 27.4 | 17.2 | 8.8 | 19 | 11.8 | 130.3 | |||||||
| 6 | Kenneth Walker III | RB | SEA | 6.7 | 17.4 | 27.6 | 13.9 | BYE | 14.9 | 11.1 | 7 | 1.7 | 18.7 | 1.6 | 12.1 | 120.6 | |||||||
| 7 | Josh Jacobs | RB | GB | 7.1 | 4.9 | 8 | 19.9 | 14.9 | 9.3 | 4.1 | 14.8 | 21.8 | 10.7 | 5.1 | 11 | 120.6 | |||||||
| 8 | D'Andre Swift | RB | CHI | 0.3 | 24.1 | 13.8 | 13.9 | 10.8 | 9.8 | 7.5 | 12.4 | 7.4 | - | 16.7 | 11.7 | 116.7 |