| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | - | 13.8 | 34.8 | 23.5 | 6.7 | 23.4 | 20.4 | 102.2 | ||||||||||||
| 2 | Tony Pollard | RB | TEN | 5.2 | 10.9 | 32.7 | - | 18.8 | 30.9 | 19.7 | 98.5 | ||||||||||||
| 3 | Joe Mixon | RB | HOU | 12.8 | 15.1 | 5.9 | 51.1 | - | 6.2 | 18.2 | 91.1 | ||||||||||||
| 4 | Kenneth Walker III | RB | SEA | 17 | 28.7 | 11.2 | 24.9 | 7.2 | BYE | 17.8 | 89 | ||||||||||||
| 5 | Travis Etienne Jr. | RB | JAC | 10.8 | 17.9 | 22.2 | 24.6 | 7.3 | BYE | 16.6 | 82.8 | ||||||||||||
| 6 | Josh Jacobs | RB | GB | - | 33.5 | 5.4 | 8.7 | 16.6 | 16 | 16 | 80.2 | ||||||||||||
| 7 | Christian McCaffrey | RB | SF | 15.8 | 6.2 | 32.3 | BYE | 13.7 | 10.6 | 15.7 | 78.6 | ||||||||||||
| 8 | Austin Ekeler | RB | WAS | 14.3 | 24.7 | - | 17.1 | 6.3 | 16 | 15.7 | 78.4 |