| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Joe Mixon | RB | HOU | 24.4 | 19.4 | 16.6 | 15 | 33.3 | 21.7 | 108.7 | |||||||||||||
| 2 | Saquon Barkley | RB | PHI | 24.7 | 11.1 | 29.9 | 7.8 | 31.8 | 21.1 | 105.3 | |||||||||||||
| 3 | Jahmyr Gibbs | RB | DET | 28 | 19.3 | 13.6 | 10.8 | 18.3 | 18 | 90 | |||||||||||||
| 4 | Derrick Henry | RB | BAL | 24.2 | 13.7 | 25.3 | 13.1 | 10.5 | 17.4 | 86.8 | |||||||||||||
| 5 | Bijan Robinson | RB | ATL | 20.3 | 16.6 | 14.5 | 26.4 | 6.3 | 16.8 | 84.1 | |||||||||||||
| 6 | De'Von Achane | RB | MIA | 8.5 | 20.7 | 24.1 | 5.2 | 16.5 | 15 | 75 | |||||||||||||
| 7 | James Cook III | RB | BUF | 9.2 | 25.3 | 6.9 | 14.5 | 14.7 | 14.1 | 70.6 | |||||||||||||
| 8 | Breece Hall | RB | NYJ | 20.1 | 8.9 | 8.5 | 8.3 | 24.1 | 14 | 69.9 |