| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 23.8 | BYE | 14.2 | 16.3 | 25.9 | 20.1 | 80.2 | |||||||||||||
| 2 | Gus Edwards | RB | FA | 27.4 | 17.2 | 8.8 | 19 | 3.7 | 15.2 | 76.1 | |||||||||||||
| 3 | Rachaad White | RB | TB | 10.9 | 23.9 | 15.8 | 11.8 | 11 | 14.7 | 73.4 | |||||||||||||
| 4 | Josh Jacobs | RB | GB | 14.8 | 21.8 | 10.7 | 5.1 | 18.5 | 14.2 | 70.9 | |||||||||||||
| 5 | Jahmyr Gibbs | RB | DET | 24.9 | BYE | 23.2 | 15.5 | 7.3 | 17.7 | 70.9 | |||||||||||||
| 6 | Joe Mixon | RB | HOU | 17 | 12.8 | 10.5 | 16 | 6 | 12.5 | 62.3 | |||||||||||||
| 7 | Austin Ekeler | RB | WAS | 16.3 | 19 | 17.5 | 5 | 4.4 | 12.4 | 62.2 | |||||||||||||
| 8 | Saquon Barkley | RB | PHI | 12.8 | 11.3 | 6.1 | 26 | 5.2 | 12.3 | 61.4 |