| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 41.7 | 11.8 | 11.2 | 21.6 | 64.7 | |||||||||||||||
| 2 | Travis Etienne Jr. | RB | JAC | 7.2 | 32.4 | 20.3 | 20 | 59.9 | |||||||||||||||
| 3 | David Montgomery | RB | DET | 32.1 | 18.9 | 3.3 | 18.1 | 54.3 | |||||||||||||||
| 4 | Zack Moss | RB | FA | 9 | 31.5 | 11.9 | 17.5 | 52.4 | |||||||||||||||
| 5 | Kyren Williams | RB | LAR | 24.7 | 5.7 | 21.8 | 17.4 | 52.2 | |||||||||||||||
| 6 | Breece Hall | RB | NYJ | 6.9 | 25.4 | 15.3 | 15.9 | 47.6 | |||||||||||||||
| 7 | Raheem Mostert | RB | LV | 2.5 | 13.8 | 31.2 | 15.8 | 47.5 | |||||||||||||||
| 8 | Derrick Henry | RB | BAL | 23.4 | 6.2 | 17.3 | 15.6 | 46.9 |