| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Kenneth Walker III | RB | SEA | 17 | 28.7 | 11.2 | 19 | 56.9 | |||||||||||||||
| 2 | Alvin Kamara | RB | NO | 12.4 | 10.5 | 33.8 | 18.9 | 56.7 | |||||||||||||||
| 3 | Christian McCaffrey | RB | SF | 15.8 | 6.2 | 32.3 | 18.1 | 54.3 | |||||||||||||||
| 4 | Rhamondre Stevenson | RB | NE | 21.1 | 15.8 | 14.3 | 17.1 | 51.2 | |||||||||||||||
| 5 | Travis Etienne Jr. | RB | JAC | 10.8 | 17.9 | 22.2 | 17 | 50.9 | |||||||||||||||
| 6 | Tony Pollard | RB | TEN | 5.2 | 10.9 | 32.7 | 16.3 | 48.8 | |||||||||||||||
| 7 | Derrick Henry | RB | BAL | - | 13.8 | 34.8 | 24.3 | 48.6 | |||||||||||||||
| 8 | D'Onta Foreman | RB | FA | 1.9 | 14.5 | 31.8 | 16.1 | 48.2 |