| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 13.8 | 34.8 | 24.3 | 48.6 | ||||||||||||||||
| 2 | D'Onta Foreman | RB | FA | 14.5 | 31.8 | 23.2 | 46.3 | ||||||||||||||||
| 3 | Alvin Kamara | RB | NO | 10.5 | 33.8 | 22.2 | 44.3 | ||||||||||||||||
| 4 | Tony Pollard | RB | TEN | 10.9 | 32.7 | 21.8 | 43.6 | ||||||||||||||||
| 5 | Nick Chubb | RB | HOU | 16.7 | 24.4 | 20.6 | 41.1 | ||||||||||||||||
| 6 | Travis Etienne Jr. | RB | JAC | 17.9 | 22.2 | 20.1 | 40.1 | ||||||||||||||||
| 7 | Kenneth Walker III | RB | SEA | 28.7 | 11.2 | 20 | 39.9 | ||||||||||||||||
| 8 | Josh Jacobs | RB | GB | 33.5 | 5.4 | 19.5 | 38.9 |