| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 10.6 | 15.6 | 29.4 | 32.9 | 15.6 | 25.2 | 24.2 | 13.7 | 25.3 | 21.4 | 192.5 | |||||||||
| 2 | Saquon Barkley | RB | PHI | 31.2 | 13.6 | 29.6 | 11.6 | BYE | 5.4 | 24.7 | 11.1 | 29.9 | 19.6 | 157.1 | |||||||||
| 3 | Alvin Kamara | RB | NO | 17 | 42 | 12.7 | 17.9 | 6.6 | 12.4 | 2.4 | 12.2 | 21.5 | 16.1 | 144.7 | |||||||||
| 4 | Jahmyr Gibbs | RB | DET | 13.4 | 10.6 | 16.3 | 19.8 | BYE | 9.1 | 28 | 19.3 | 13.6 | 16.3 | 130.1 | |||||||||
| 5 | Kyren Williams | RB | LAR | 11.4 | 11.2 | 29.6 | 16.4 | 14.5 | BYE | 19.6 | 17.6 | 9.5 | 16.2 | 129.8 | |||||||||
| 6 | Bijan Robinson | RB | ATL | 11.1 | 12.2 | 11.2 | 7.4 | 7.7 | 22.5 | 20.3 | 16.6 | 14.5 | 13.7 | 123.5 | |||||||||
| 7 | James Cook III | RB | BUF | 10.3 | 27.5 | 14.7 | 4.8 | 15.9 | - | 9.2 | 25.3 | 6.9 | 14.3 | 114.6 | |||||||||
| 8 | Joe Mixon | RB | HOU | 23.8 | 5 | - | - | - | 25.2 | 24.4 | 19.4 | 16.6 | 19.1 | 114.4 |