Wednesday’s MLB DFS main slate is a matinee affair, starting at 12:15 p.m. ET on DraftKings and at 1:05 p.m. ET on FanDuel, featuring 10 games on both sites. The Underdog pick ’em choices are also from 13 games that begin between 12:15 p.m. ET and 4:10 p.m. ET.
Wednesday’s Top MLB DFS Picks & Player Props
Wednesday’s Starting Pitcher Rankings (4/1)
Cristopher Sanchez is coming off a career year and opened his 2026 season with six scoreless innings and 10 strikeouts in a win. The lefty is downright dastardly at home.
According to FanGraphs, in 16 home starts spanning 97.2 innings at home since last year, Sanchez has dominated opponents to the tune of a 1.94 ERA, 2.43 xFIP, 0.90 WHIP, 4.5 BB%, and 30.5 K%. Five of the projected starters for the Nationals have had a 96 wRC+ or worse against lefties since 2024, and five have had at least a 26.5 K%. Thus, the matchup is sweet.
The betting info is arguably even tastier. The Phillies are -260 favorites, and the game’s total is 8.5 runs. Sanchez is my favorite pitching selection across all game types on today’s matinee slate.
Kevin Gausman’s 2025 stats were rock-solid or slightly better, but they weren’t ace material. However, he pitched like an ace in his season opener at home against the Athletics. The 35-year-old righty allowed only a solo homer with 11 strikeouts across six innings.
Gausman leaned heavily on his splitter, and he had a fabulous 19.3 SwStr% against the A’s. The veteran righty has an even softer matchup in his second start of the year. Colorado’s projected starting lineup features only one hitter with a wRC+ above 100 against righties since 2024, and eight of the hitters have had at least a 24.3 K%, with seven tallying at least a 26.7 K%.
Understandably, the Blue Jays are commanding -267 favorites. The game’s total is 8.0 runs, which is also favorable for Gausman, given how heavily favored Toronto is. Sanchez and Gausman are the ideal cash game pairing on Wednesday’s slate, but it’s also a high-ceiling duo for GPPs.
Trevor Rogers’ sub-2.00 ERA in 18 starts, totaling 109.2 innings last year, was admittedly lucky. Still, the lefty’s 3.40 xERA, 3.64 xFIP, 3.75 SIERA, 0.90 WHIP, and 24.3 K% were nothing to sneeze at.
Rogers has delighted O’s faithful in their home digs as well. In eight home starts spanning 47 innings since last year, he’s twirled a 0.96 ERA, 3.47 xFIP, 0.70 WHIP, 5.3 BB%, and 26.3 K%.
The lefty can keep cooking at home against the Rangers today. Only one of the projected starters for Texas has posted a wRC+ north of 110 against lefties since 2024, and five have had a 100 wRC+ or lower. Moreover, all of the projected starters have had at least a 21.1 K%, and six have had at least a 23.7 K% against lefties during that period. Rogers is a high-ceiling pivot from Sanchez and Gausman in GPPs.
Suggested Lineup Stacks
Cade Cavalli was rather ho-hum in 10 starts last year, amassing a 4.25 ERA, 4.14 xERA, 3.93 xFIP, 4.09 SIERA, 1.48 WHIP, 6.8 BB%, and 18.3 K%. He was also a disaster on the road, with a 6.17 ERA, 1.76 WHIP, 7.1 BB%, and 13.4 K% in five road tilts.
Cavalli didn’t do anything to reverse his fortunes on the road in his first start of the year. The righty ceded three runs (two earned) on three hits and three walks in only 3.2 innings on Opening Day. The Phillies have a potent offense that should exacerbate Cavalli’s road woes this afternoon.
Coors Field doesn’t do Kyle Freeland any favors. The veteran lefty isn’t merely a victim of his hitting paradise for a home field, though. Instead, he’s had a 4.36 ERA, 4.32 xFIP, 1.28 WHIP, 5.0 BB%, and 16.8 K% in 95 innings on the road since last year. In addition, Colorado’s relievers have a 5.14 ERA this year after the bullpen posted a 5.18 ERA in 2025. Even with some fresh faces following offseason bullpen churning, Colorado’s relievers remain a group opposing hitters should be elated to see. The Blue Jays can light up the scoreboard on Wednesday afternoon.
Core Studs
- Kyle Schwarber has drilled 60 dongs with a .353 OBP, .289 ISO, .367 wOBA, and 135 wRC+ in 898 plate appearances against righties since 2024.
- Bryce Harper is a beast with the platoon advantage at home. In 570 plate appearances against right-handed pitching at home since 2023, Harper has launched 32 long-balls with a .421 OBP, .422 wOBA, and 169 wRC+.
- Cavalli has been at his worst against righties, permitting a .433 OBP, .511 SLG, and .410 wOBA to 104 of them since last season. Meanwhile, Trea Turner sits atop Philadelphia’s lineup and has a 117 wRC+ against righties since 2024.
Value Plays/Punts
- Ernie Clement is an above-average hitter with the platoon advantage, hitting nine homers with a .305 OBP, .186 ISO, .327 wOBA, and 112 wRC+ in 335 plate appearances against southpaws since 2024.
- Marcell Ozuna will face a lefty at homer-friendly Great American Ball Park today. He has hit eight homers with a .397 OBP, .154 ISO, .365 wOBA, and 134 wRC+ in 308 plate appearances against lefties since 2024.
- Matt Shaw has ripped six round-trippers with a .319 OBP, .233 ISO, .345 wOBA, and 124 wRC+ in 113 plate appearances against lefties since reaching The Show last season.
Wednesday’s Top 3 Underdog Player Props
Check out our best picks on the MLB Underdog Cheat Sheet 
Alec Bohm’s outlook is bright today against Cavalli’s reverse platoon split. Again, Cavalli has allowed a .410 wOBA to 104 right-handed batters since last season. Meanwhile, Bohm has hit 17 homers with a .328 OBP, .138 ISO, .323 wOBA, and 105 wRC+ in 804 plate appearances against righties since 2024.
Griffin Conine has logged a hit, run, or RBI in all three of his starts this year. He also has 31 hits, a .250 batting average, .316 OBP, .177 ISO, .324 wOBA, and 106 wRC+ in 136 career plate appearances against righties. Conversely, Shane Smith has surrendered 69 hits, a .225 batting average, and .318 wOBA to 345 left-handed batters faced since last season. We project Conine to have 1.42 hits plus runs and RBI on Wednesday.
Garrett Crochet began his 2026 with six innings of scoreless ball after spinning a 2.59 ERA, 2.88 xERA, 2.64 xFIP, and 2.86 SIERA in 32 starts spanning 205.1 innings last year. Crochet averaged over 19 outs per start last year and cleared 17.5 outs in 26 of 33 starts since last season. He should accomplish the feat of recording at least 18 outs against the Astros.
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Josh Shepardson is a featured writer at FantasyPros. For more from Josh, check out his archive and follow him @BChad50.
