Head coach Brandon Staley praised Guyton for his impressive work as of late, saying, "Jalen Guyton was fantastic in the offseason. This guy made a lot of big plays for us in the spring. He came in, physically, just in great shape. He's moving great. I thought that he was able to move around. He really did a nice job on special teams." Although Josh Palmer has been taking first-team reps alongside Keenan Allen and Mike Williams, Guyton certainly remains in the mix as the offseason continues. In 2021, he caught 31 passes for 448 yards and three touchdowns. He also made his returning debut last season, totaling 32 yards on two kickoffs.