Brandon Aiyuk

The 49ers are expected to release WR Brandon Aiyuk.

Fantasy Impact

Aiyuk could be released as soon as Wednesday. The Commanders remains the most likely destination for him to reunite with Jayden Daniels.

San Francisco 49ers general manager John Lynch said that it's "safe to say [wide receiver Brandon Aiyuk] played his last snap" with the team.

Fantasy Impact

Aiyuk ended his 2024 season on the injured reserve after he tore his ACL and MCL in October. He opened 2025 on the Physically Unable to Perform list and never played a snap after reportedly stepping away from the team. In December, he was placed on the reserve/left squad list, ending his year. He does not seem likely to remain with the 49ers in 2026, and his status around the league is up in the air after an unceremonious exit.

Brandon Aiyuk has been placed on the reserve/left squad list by the 49ers.

Fantasy Impact

This move by the 49ers ultimately ends any hope of Aiyuk making a late-season return. The two sides have been at odds for a while now, and the team has simply decided to move on. Aiyuk will have the chance to sign with a new team during the upcoming offseason.

49ers GM John Lynch said he’s “hopeful” WR Brandon Aiyuk will play for the team this season.

Fantasy Impact

Lynch couldn't fully commit to Aiyuk playing this season, but he said he is hopeful. He will not have his practice window opened this week.

The 49ers will not open the practice window for Brandon Aiyuk this week.

Fantasy Impact

Aiyuk had 2026 guarantees voided on his contract. It is seeming more unlikely that he plays this week.