Brandon Aiyuk Fantasy Football Outlook (2025)

By Derek Brown (FantasyPros), Thu, Aug 14th 2025, 1:02pm EDT

Brandon Aiyuk tore his ACL in Week 7 of last season, so it's up in the air how effective Aiyuk will be this season and when he'll be back to full strength. The latest news regarding Aiyuk puts him around Week 6 to return to action. When Aiyuk was on the field last year, he was filling the box scores with disappointing stat lines as the WR55 in fantasy points per game. He didn't score a single touchdown and managed only one game with more than 50 receiving yards. Overall, he had a 20.5% target share, 1.85 yards per route run, a 21.7% first-read share, and 0.095 first downs per route run (per Fantasy Points Data). Those are solid marks, but they don't match up with his still stellar per-route numbers. Among 112 qualifying receivers last season, Aiyuk led the NFL in separation and route win rate. Aiyuk is a decent dart throw in 2025, but don't count on him to be a major contributor to any fantasy team until possibly late in the season.