Deebo Samuel Sr. Week 5 Outlook - 49ers at Seahawks

By Derek Brown (FantasyPros), Thu, Oct 8th 2026, 1:35pm EDT

Deebo Samuel has been balling this season as the WR16 in fantasy points per game. Samuel has had some rushing production, padding his fantasy stats with seven carries and 74 yards on the ground. He has touchdowns in three of the 49ers' four games this season. Samuel has a 14.2% target share with 2.31 YPRR, five red zone targets, zero deep targets, and a 15.1% first-read share. This week, he'll face a Seattle secondary that has utilized two high at the ninth-highest rate in the NFL (59.1%). Against two high, he has seen his numbers suffer this season, with Mike Evans and George Kittle leading the way against this coverage. Samuel has only a 15% TPRR and 1.11 YPRR against two high this season. With a tough matchup incoming this week, temper your expectations. Seattle has allowed the sixth-fewest yards per target and the seventh-fewest fantasy points per opportunity to perimeter wide receivers.