James Cook III

James Cook led the NFL in rushing yards in 2025 (1,621). He finished as the RB6 in PPG and RB6 in total points scored. At 26 years old, the Bills RB is in his Uber Prime. He is improving every single season. And he has yet to be fully unlocked as a receiver despite being heavily touted as a pass-catcher coming out of Georgia. If Cook gets unleashed on all three downs under a new HC, he could flirt with an RB1 overall status as the engine to the Bills' offense. The 200-pound back has a 44-catch and 445 receiving yards season on his resume, which only Bijan Robinson, Jahmyr Gibbs, Christian McCaffery, and De'Von Achane hit last season with 1,000 rushing yards to boot.

Well, so much for all of the regression talk about James Cook last year. Cook crushed all of the haters, improving his stock as the RB6 in fantasy points per game. He led the NFL in rushing yards (1,621) while finishing third in rushing attempts and sixth in rushing touchdowns (tied). Cook had 14 total touchdowns compared to the 18 that he spiked in the previous season. Cook remained extremely efficient as a rusher, ranking 15th in explosive run rate and 11th in yards after contact per attempt (per Fantasy Points Data). His passing game usage was nearly identical to the previous season, with 40 targets (38 targets in 2024) and 8.8 yards per reception (8.1 in 2024). We can quibble about where Cook sits in the RB1 rankings in 2026, but he remains a rock-solid RB1 in one of the best offenses in the NFL.