James Cook III

James Cook led the NFL in rushing yards in 2025 (1,621). He finished as the RB6 in PPG and RB6 in total points scored. At 26 years old, the Bills RB is in his Uber Prime. He is improving every single season. And he has yet to be fully unlocked as a receiver despite being heavily touted as a pass-catcher coming out of Georgia. If Cook gets unleashed on all three downs under a new HC, he could flirt with an RB1 overall status as the engine to the Bills' offense. The 200-pound back has a 44-catch and 445 receiving yards season on his resume, which only Bijan Robinson, Jahmyr Gibbs, Christian McCaffery, and De'Von Achane hit last season with 1,000 rushing yards to boot.

James Cook III rushed for 15 yards on two carries in the Bills 35-8 win over the Jets.

Fantasy Impact

Cook and the majority of the Bills' starters on offense were used sparingly in the win over the Jets. Cook turned in an excellent season, finishing with 1,621 rushing yards and 12 touchdowns on 309 carries this season. He will remain a highly sought after pick in fantasy drafts in 2026.