| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 25.9 | 22.5 | 22.9 | 48.7 | 13.8 | 14.2 | 22.6 | 29.8 | BYE | 20.2 | 24.5 | 220.6 | ||||||||
| 2 | Raheem Mostert | RB | LV | 13 | 25.7 | 45.2 | 5.5 | 15.8 | 34.2 | 6.1 | 10.6 | 14.5 | - | 19 | 170.6 | ||||||||
| 3 | Travis Etienne Jr. | RB | JAC | 21.4 | 6.2 | 17.8 | 10.2 | 36.4 | 23.3 | 22.7 | 25.9 | BYE | 6.4 | 18.9 | 170.3 | ||||||||
| 4 | Josh Jacobs | RB | GB | 9.1 | 9.9 | 11 | 27.9 | 19.9 | 11.3 | 5.1 | 16.8 | 21.8 | 12.7 | 14.6 | 145.5 | ||||||||
| 5 | Alvin Kamara | RB | NO | - | - | - | 21.4 | 18.7 | 17.4 | 29.3 | 27 | 11 | 18.5 | 20.5 | 143.3 | ||||||||
| 6 | Brian Robinson Jr. | RB | SF | 13.6 | 28.9 | 7 | 13.1 | 8.3 | 13.6 | 8.3 | 9.9 | 11.7 | 27.7 | 14.2 | 142.1 | ||||||||
| 7 | Kenneth Walker III | RB | SEA | 10.7 | 18.4 | 30.6 | 13.9 | BYE | 17.9 | 13.1 | 8 | 2.7 | 19.7 | 15 | 135 | ||||||||
| 8 | Rachaad White | RB | TB | 6.9 | 21.3 | 7.2 | 10.8 | BYE | 6.8 | 15.9 | 17.9 | 27.9 | 17.8 | 14.7 | 132.5 |