| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Austin Ekeler | RB | WAS | 34.9 | 35.9 | 24.3 | 36.7 | - | 24.1 | 13.3 | 18 | 26.7 | 187.2 | ||||||||||
| 2 | Josh Jacobs | RB | GB | 34.5 | 30.3 | - | 36.5 | 7.4 | 11.7 | 22.6 | 19 | 23.1 | 162 | ||||||||||
| 3 | Derrick Henry | RB | BAL | 23.7 | 27.2 | - | 16.8 | 35.8 | 23.5 | 8.7 | 25.4 | 23 | 161.1 | ||||||||||
| 4 | Christian McCaffrey | RB | SF | 25.8 | 23.4 | 22.8 | 8.2 | 40.3 | BYE | 17.7 | 17.6 | 22.3 | 155.8 | ||||||||||
| 5 | Joe Mixon | RB | HOU | 17.4 | 11.8 | 16.8 | 18.1 | 12.9 | 55.1 | - | 9.2 | 20.2 | 141.3 | ||||||||||
| 6 | Rhamondre Stevenson | RB | NE | 12.9 | 19.5 | 25.1 | 23.8 | 21.3 | 16 | BYE | 14.2 | 19 | 132.8 | ||||||||||
| 7 | Alvin Kamara | RB | NO | - | 23.4 | 18.4 | 17.5 | 42.8 | 9.2 | 7.5 | 12.9 | 18.8 | 131.7 | ||||||||||
| 8 | Tony Pollard | RB | TEN | 1.8 | 14.6 | 7.2 | 12.9 | 33.7 | - | 21.8 | 36.9 | 18.4 | 128.9 |