| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 21.7 | - | 27.5 | 37.6 | 26.1 | 30.1 | 34.3 | 29.6 | 177.3 | ||||||||||
| 2 | Dalvin Cook | RB | FA | 13.4 | 27.9 | 28.1 | 15.6 | 31.3 | 16.7 | - | 22.2 | 133 | ||||||||||
| 3 | Leonard Fournette | RB | FA | 17.8 | 16.5 | 20.6 | 12.2 | - | 12.7 | 36.9 | 19.5 | 116.7 | ||||||||||
| 4 | Derrick Henry | RB | BAL | 4.3 | 17.8 | 7.3 | 24.9 | 33.1 | - | 28.5 | 19.3 | 115.9 | ||||||||||
| 5 | Ezekiel Elliott | RB | FA | 26.3 | 26.7 | - | 13.9 | 8.3 | 19.3 | 16.6 | 18.5 | 111.1 | ||||||||||
| 6 | Aaron Jones Sr. | RB | MIN | 8 | 18.3 | 41.6 | 3.9 | 27.3 | - | 3.8 | 17.2 | 102.9 | ||||||||||
| 7 | Nick Chubb | RB | HOU | 28.9 | - | 10.8 | 13.1 | 14.1 | 9.2 | 25.4 | 16.9 | 101.5 | ||||||||||
| 8 | Latavius Murray | RB | FA | 10.9 | 32 | 36.7 | - | 3.9 | 5.2 | 12.4 | 16.9 | 101.1 |