| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 9.8 | 34.3 | 17.6 | 35.1 | 27.2 | 17.4 | 23.6 | 141.4 | ||||||||||||
| 2 | Jahmyr Gibbs | RB | DET | BYE | 5.8 | 38.2 | 19.6 | 55.4 | 11.6 | 26.1 | 130.6 | ||||||||||||
| 3 | James Cook III | RB | BUF | 33.6 | 13.5 | 10.7 | 20.4 | 21.9 | 18.7 | 19.8 | 118.8 | ||||||||||||
| 4 | Jonathan Taylor | RB | IND | 37.4 | 7.7 | 49.6 | BYE | 8.6 | 15.1 | 23.7 | 118.4 | ||||||||||||
| 5 | De'Von Achane | RB | MIA | 20.1 | 16.6 | 40.5 | 21.5 | BYE | 19.4 | 23.6 | 118.1 | ||||||||||||
| 6 | Bijan Robinson | RB | ATL | 5.8 | 17.6 | 10.8 | 30.3 | 14.7 | 30.3 | 18.3 | 109.5 | ||||||||||||
| 7 | Derrick Henry | RB | BAL | 19.1 | 13.1 | 11.4 | 20.2 | 22.8 | 17.4 | 17.3 | 104 | ||||||||||||
| 8 | TreVeyon Henderson | RB | NE | 5.5 | 12.7 | 28 | 32.3 | 11.1 | 11.6 | 16.9 | 101.2 |