| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 28.8 | 18 | 21.2 | 34 | 25.5 | 102 | ||||||||||||||
| 2 | Joe Mixon | RB | HOU | 26.3 | 11.9 | 25.1 | 28 | 22.8 | 91.3 | ||||||||||||||
| 3 | James Conner | RB | ARI | 8.1 | 12.4 | 14.2 | 40.3 | 18.8 | 75 | ||||||||||||||
| 4 | Alvin Kamara | RB | NO | BYE | 33.9 | 16.6 | 20.4 | 23.6 | 70.9 | ||||||||||||||
| 5 | Damien Harris | RB | FA | 17.8 | 25.3 | 14 | 10.3 | 16.9 | 67.4 | ||||||||||||||
| 6 | Darrell Henderson Jr. | RB | FA | 24.7 | 9.4 | 22.3 | 8.8 | 16.3 | 65.2 | ||||||||||||||
| 7 | Najee Harris | RB | LAC | 24.7 | BYE | 21 | 16.8 | 20.8 | 62.5 | ||||||||||||||
| 8 | Darrel Williams | RB | FA | 23.9 | 8 | 17 | 10.7 | 14.9 | 59.6 |