| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 28.9 | 27.8 | 15 | 18.2 | 32 | 18.6 | 23.4 | 140.5 | ||||||||||||
| 2 | James Conner | RB | ARI | 9.7 | 7.1 | 12.4 | 14.2 | 35.3 | 12.4 | 15.2 | 91.1 | ||||||||||||
| 3 | Joe Mixon | RB | HOU | 9.5 | 21.3 | 11.9 | 21.1 | 23 | BYE | 17.4 | 86.8 | ||||||||||||
| 4 | Derrick Henry | RB | BAL | 31 | 33.6 | 14.4 | 6.8 | - | - | 21.5 | 85.8 | ||||||||||||
| 5 | Najee Harris | RB | LAC | 20.2 | 18.7 | BYE | 18 | 13.8 | 13.3 | 16.8 | 84 | ||||||||||||
| 6 | Alvin Kamara | RB | NO | 24.2 | BYE | 23.9 | 13.6 | 16.4 | - | 19.5 | 78.1 | ||||||||||||
| 7 | Darrell Henderson Jr. | RB | FA | 15.9 | 22.7 | 6.4 | 21.3 | 5.8 | 4.1 | 12.7 | 76.2 | ||||||||||||
| 8 | Damien Harris | RB | FA | 9.8 | 16.8 | 23.3 | 14 | 9.3 | - | 14.6 | 73.2 |