| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 11.6 | 5.3 | 7.2 | 17.4 | 28.9 | 27.8 | 15 | 18.2 | 32 | 18.6 | 50.4 | 21.1 | 232.4 | |||||||
| 2 | Austin Ekeler | RB | WAS | 11.7 | 13.5 | 16.7 | 26.5 | 27.9 | 5.5 | - | 18.4 | 8.2 | 11.9 | 35.5 | 17.6 | 175.8 | |||||||
| 3 | Derrick Henry | RB | BAL | 7.7 | 41.7 | 16.4 | 23.7 | 31 | 33.6 | 14.4 | 6.8 | - | - | - | 21.9 | 175.3 | |||||||
| 4 | Joe Mixon | RB | HOU | 21 | 7.1 | 9.4 | 12.7 | 9.5 | 21.3 | 11.9 | 21.1 | 23 | BYE | 24.3 | 16.1 | 161.3 | |||||||
| 5 | James Conner | RB | ARI | 5.3 | 2.6 | 17.3 | 18.6 | 9.7 | 7.1 | 12.4 | 14.2 | 35.3 | 12.4 | 15.9 | 13.7 | 150.8 | |||||||
| 6 | Najee Harris | RB | LAC | 4.9 | 14.1 | 14.2 | 15.1 | 20.2 | 18.7 | BYE | 18 | 13.8 | 13.3 | 11.9 | 14.4 | 144.2 | |||||||
| 7 | Ezekiel Elliott | RB | FA | 3.9 | 15.7 | 23.6 | 20.3 | 23.2 | 11.9 | - | 7.3 | 9.6 | 17.8 | 6.8 | 14 | 140.1 | |||||||
| 8 | Nick Chubb | RB | HOU | 20.1 | 15.8 | 8.4 | 10.5 | 23 | - | - | 6.9 | 28.3 | BYE | 20.4 | 16.7 | 133.4 |