| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 8.2 | 8.5 | 20.3 | 20.7 | 25.2 | - | 13.8 | 34.8 | 23.5 | 6.7 | 23.4 | 18.5 | 185.1 | |||||||
| 2 | Nick Chubb | RB | HOU | 14.3 | 29.3 | 17.3 | 18.7 | 25.4 | 7 | 16.7 | 24.4 | - | 12.1 | 6.7 | 17.2 | 171.9 | |||||||
| 3 | Austin Ekeler | RB | WAS | 7.2 | 9.4 | 5.3 | 28.9 | 31.9 | 14.3 | 24.7 | - | 17.1 | 6.3 | 16 | 16.1 | 161.1 | |||||||
| 4 | Josh Jacobs | RB | GB | 7.3 | 8.1 | 9.7 | 29.5 | 25.3 | - | 33.5 | 5.4 | 8.7 | 16.6 | 16 | 16 | 160.1 | |||||||
| 5 | Saquon Barkley | RB | PHI | 27.4 | 8.8 | 18.6 | 16.2 | 16.6 | 15.5 | 13.5 | 12.2 | - | 22 | 3.5 | 15.4 | 154.3 | |||||||
| 6 | Christian McCaffrey | RB | SF | 11.7 | 12.8 | 11.5 | 16.8 | 16.4 | 15.8 | 6.2 | 32.3 | BYE | 13.7 | 10.6 | 14.8 | 147.8 | |||||||
| 7 | Jamaal Williams | RB | FA | 15 | 6 | 22.7 | 22.9 | 5.6 | - | 6.3 | 19.6 | 10.1 | 11.9 | 24.4 | 14.5 | 144.5 | |||||||
| 8 | Tony Pollard | RB | TEN | 2.2 | 15.8 | 10.5 | 0.8 | 14.6 | 5.2 | 10.9 | 32.7 | - | 18.8 | 30.9 | 14.2 | 142.4 |