| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 20.7 | 25.2 | - | 13.8 | 34.8 | 23.5 | 6.7 | 23.4 | 21.2 | 148.1 | ||||||||||
| 2 | Austin Ekeler | RB | WAS | 28.9 | 31.9 | 14.3 | 24.7 | - | 17.1 | 6.3 | 16 | 19.9 | 139.2 | ||||||||||
| 3 | Josh Jacobs | RB | GB | 29.5 | 25.3 | - | 33.5 | 5.4 | 8.7 | 16.6 | 16 | 19.3 | 135 | ||||||||||
| 4 | Tony Pollard | RB | TEN | 0.8 | 14.6 | 5.2 | 10.9 | 32.7 | - | 18.8 | 30.9 | 16.3 | 113.9 | ||||||||||
| 5 | Joe Mixon | RB | HOU | 13.4 | 8.8 | 12.8 | 15.1 | 5.9 | 51.1 | - | 6.2 | 16.2 | 113.3 | ||||||||||
| 6 | Christian McCaffrey | RB | SF | 16.8 | 16.4 | 15.8 | 6.2 | 32.3 | BYE | 13.7 | 10.6 | 16 | 111.8 | ||||||||||
| 7 | Nick Chubb | RB | HOU | 18.7 | 25.4 | 7 | 16.7 | 24.4 | - | 12.1 | 6.7 | 15.9 | 111 | ||||||||||
| 8 | Dalvin Cook | RB | FA | 8.6 | 24.1 | 14.3 | - | 20.1 | 11.6 | 20.6 | 7.2 | 15.2 | 106.5 |