| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | James Cook III | RB | BUF | 33.6 | 12.5 | 5.7 | 17.4 | 18.9 | 15.7 | 9.1 | 29.1 | 17.8 | 142 | ||||||||||
| 2 | Jahmyr Gibbs | RB | DET | BYE | 2.8 | 35.2 | 14.6 | 44.4 | 8.6 | 30 | 5.8 | 20.2 | 141.4 | ||||||||||
| 3 | Jonathan Taylor | RB | IND | 35.4 | 5.7 | 46.6 | BYE | 6.6 | 12.1 | 11.4 | 10.1 | 18.3 | 127.9 | ||||||||||
| 4 | De'Von Achane | RB | MIA | 15.1 | 10.6 | 34.5 | 16.5 | BYE | 19.4 | 16.5 | 12.7 | 17.9 | 125.3 | ||||||||||
| 5 | Christian McCaffrey | RB | SF | 6.8 | 29.3 | 9.6 | 30.1 | 20.2 | 13.4 | BYE | 14.7 | 17.7 | 124.1 | ||||||||||
| 6 | Derrick Henry | RB | BAL | 19.1 | 12.1 | 8.4 | 18.2 | 20.8 | 16.4 | 10.2 | 10 | 14.4 | 115.2 | ||||||||||
| 7 | Travis Etienne Jr. | RB | JAC | BYE | 11.5 | 13.7 | 19.3 | 17.6 | 4.1 | 20.2 | 28.5 | 16.4 | 114.9 | ||||||||||
| 8 | Bijan Robinson | RB | ATL | 2.8 | 9.6 | 8.8 | 26.3 | 12.7 | 25.3 | 7.4 | 21.5 | 14.3 | 114.4 |