| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Derrick Henry | RB | BAL | 10.6 | 15.6 | 29.4 | 32.9 | 15.6 | 20.8 | 104.1 | |||||||||||||
| 2 | Alvin Kamara | RB | NO | 17 | 42 | 12.7 | 17.9 | 6.6 | 19.2 | 96.2 | |||||||||||||
| 3 | Saquon Barkley | RB | PHI | 31.2 | 13.6 | 29.6 | 11.6 | BYE | 21.5 | 86 | |||||||||||||
| 4 | Kyren Williams | RB | LAR | 11.4 | 11.2 | 29.6 | 16.4 | 14.5 | 16.6 | 83.1 | |||||||||||||
| 5 | Jordan Mason | RB | MIN | 21.2 | 16.4 | 8.8 | 22 | 7.8 | 15.2 | 76.2 | |||||||||||||
| 6 | James Cook III | RB | BUF | 10.3 | 27.5 | 14.7 | 4.8 | 15.9 | 14.6 | 73.2 | |||||||||||||
| 7 | Brian Robinson Jr. | RB | SF | 14.9 | 13.6 | 9.7 | 17.3 | 13.8 | 13.9 | 69.3 | |||||||||||||
| 8 | Jonathan Taylor | RB | IND | 10.8 | 13.5 | 25.5 | 16.8 | - | 16.7 | 66.6 |