| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 22.9 | 19.5 | 17.9 | 41.7 | 11.8 | 11.2 | 20.8 | 125 | ||||||||||||
| 2 | Raheem Mostert | RB | LV | 11 | 24.7 | 38.2 | 2.5 | 13.8 | 31.2 | 20.2 | 121.4 | ||||||||||||
| 3 | Kyren Williams | RB | LAR | 17.4 | 22 | 6.5 | 24.7 | 5.7 | 21.8 | 16.4 | 98.1 | ||||||||||||
| 4 | Travis Etienne Jr. | RB | JAC | 16.4 | 4.2 | 13.8 | 7.2 | 32.4 | 20.3 | 15.7 | 94.3 | ||||||||||||
| 5 | De'Von Achane | RB | MIA | - | 0.9 | 47.3 | 24 | 20.5 | - | 23.2 | 92.7 | ||||||||||||
| 6 | Zack Moss | RB | FA | - | 16.7 | 20.5 | 9 | 31.5 | 11.9 | 17.9 | 89.6 | ||||||||||||
| 7 | Kenneth Walker III | RB | SEA | 6.7 | 17.4 | 27.6 | 13.9 | BYE | 14.9 | 16.1 | 80.5 | ||||||||||||
| 8 | David Montgomery | RB | DET | 13.4 | 11.4 | - | 32.1 | 18.9 | 3.3 | 15.8 | 79.1 |