| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Alvin Kamara | RB | NO | 17.4 | 12.4 | 10.5 | 33.8 | 18.5 | 74.1 | ||||||||||||||
| 2 | Derrick Henry | RB | BAL | 25.2 | - | 13.8 | 34.8 | 24.6 | 73.8 | ||||||||||||||
| 3 | Nick Chubb | RB | HOU | 25.4 | 7 | 16.7 | 24.4 | 18.4 | 73.5 | ||||||||||||||
| 4 | Kenneth Walker III | RB | SEA | 14.8 | 17 | 28.7 | 11.2 | 17.9 | 71.7 | ||||||||||||||
| 5 | Austin Ekeler | RB | WAS | 31.9 | 14.3 | 24.7 | - | 23.6 | 70.9 | ||||||||||||||
| 6 | Christian McCaffrey | RB | SF | 16.4 | 15.8 | 6.2 | 32.3 | 17.7 | 70.7 | ||||||||||||||
| 7 | Rhamondre Stevenson | RB | NE | 17.5 | 21.1 | 15.8 | 14.3 | 17.2 | 68.7 | ||||||||||||||
| 8 | Josh Jacobs | RB | GB | 25.3 | - | 33.5 | 5.4 | 21.4 | 64.2 |