| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 27.8 | 15 | 18.2 | 32 | 23.3 | 93 | ||||||||||||||
| 2 | Joe Mixon | RB | HOU | 21.3 | 11.9 | 21.1 | 23 | 19.3 | 77.3 | ||||||||||||||
| 3 | James Conner | RB | ARI | 7.1 | 12.4 | 14.2 | 35.3 | 17.3 | 69 | ||||||||||||||
| 4 | Damien Harris | RB | FA | 16.8 | 23.3 | 14 | 9.3 | 15.9 | 63.4 | ||||||||||||||
| 5 | Darrell Henderson Jr. | RB | FA | 22.7 | 6.4 | 21.3 | 5.8 | 14.1 | 56.2 | ||||||||||||||
| 6 | Derrick Henry | RB | BAL | 33.6 | 14.4 | 6.8 | - | 18.3 | 54.8 | ||||||||||||||
| 7 | Alvin Kamara | RB | NO | BYE | 23.9 | 13.6 | 16.4 | 18 | 53.9 | ||||||||||||||
| 8 | Najee Harris | RB | LAC | 18.7 | BYE | 18 | 13.8 | 16.8 | 50.5 |