Today is a day that ends in y, which means it’s a great day to fire up a fantasy football mock draft using FantasyPros’ Draft Wizard. I recently completed a a half-PPR mock draft (the superior format), picking as the final of 12 teams. Roster settings for this mock will be 1-QB, 2-RB, 3-WR, 1-TE, 1-Flex and six bench slots. I’m picking at the turn, so and I’ll share a few of my favorite picks from the draft to help you navigate your 2025 drafts.
Fantasy Football Draft Picks to Target
1.12/2.01: Nico Collins (WR – HOU) & De’Von Achane (RB – MIA)
First things first, I am going to be grouping each pair of back-to-back picks. Each time I was on the clock, I decided on both players I wanted before selecting either, and I only randomly chose who I technically selected first. With that in mind, it doesn’t make sense to separate them (and by the way, you should always use this approach when faced with back-to-back picks).
With that said, this first pair of picks was pretty easy. Especially drafting against fantasy football ADP, which tends to be more running back-heavy than expert rankings, I knew I wanted to select at least one running back at this turn. But Nico Collins, an elite talent with legitimate WR1 overall upside, was the clear top player on my board.
That meant the only real decision here was whether I wanted to take De’Von Achane or Derrick Henry as my RB1 to pair with Collins. And, although I love King Henry, it’s hard to bank on a 31-year-old non-pass-catcher in any kind of PPR format. Achane, meanwhile, has shown he can provide elite fantasy numbers with either elite rushing efficiency (which he did as a rookie) or absurd receiving volume (which he did last year).
3.12/4.01: Davante Adams (WR – LAR) & Omarion Hampton (RB – LAC)
This was another relatively easy decision, as I didn’t have to think much before grabbing these two new residents of the City of Angels. I don’t know if the ADP I drafted against included a dip in Davante Adams’ value in response to Matthew Stafford‘s current injury situation, but I am happy to scoop that value if so.
Adams would be more impacted by Stafford missing time than Puka Nacua. As of now, I don’t think Stafford will miss time. That leaves Adams as the clear No. 2 WR on an efficient Sean McVay offense that targets receivers more than any other team in the league.
As for Omarion Hampton, he was already an excellent bet as a first-round rookie with a three-down skill set. But now things are only getting better for him as it looks less and less likely that Najee Harris will be ready in time for Week 1. If that is the case, we don’t have to worry about Hampton starting slowly in his NFL debut. Taking him over established vets like Alvin Kamara feels risky now, but it could very easily be a no-brainer just a few weeks into the season.
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Ted Chmyz is a fantasy football contributor for FantasyPros.com. Find him on Twitter and Bluesky @Tchmyz for more fantasy content or to ask questions.