NFL DFS Lineup Advice: Best Stacks (Week 18)

The 2025 NFL regular season concludes on Sunday with a massive 13-game slate. We’ve got a ton of high upside prospects and players to stack in DraftKings and FanDuel NFL DFS contests, even with most teams now cemented or eliminated from playoff contention.

Notable games we’ll be diving into to build some of the best Week 18 stacks include the Saints vs. Falcons, Cowboys vs. Giants, and Titans vs. Jaguars. Every game is a divisional matchup, so expect a lot of upsets and aggressive play calling, with incentive bonuses and future roster spots at stake.

Let’s build some of the best stacks during Sunday’s regular season finale within NFL Week 18 contests on DraftKings and FanDuel. Follow me on X at Matt_MacKay_ for more NFL analysis and free picks.

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NFL DFS Week 18: Best DFS Stacks

DraftKings Salary: $50,000 | FanDuel Salary: $60,000

New Orleans Saints vs. Atlanta Falcons

The NFC South pits the Saints and Falcons in a Week 18 matchup at Mercedes-Benz Superdome. Oddsmakers are on the Falcons as a -3.5 home favorite with a 43.5 point total.

Key starters out for this game either out or questionable include a pair of star wideouts, Chris Olave and Drake London. Falcons’ TE1, Kyle Pitts, is also questionable with a knee injury.

Cousins beat the Saints during his first start for Atlanta a few weeks ago and has helped the offense find a rhythm with some big wins. Shough has developed quickly since taking over as QB1 in New Orleans, so we’re going to see some quality quarterback play in this game.

Cousins has a more difficult matchup on paper than Shough. We’ll pair the veteran with WR David Sills V, who logged 13.8 fantasy points against Tampa Bay in Week 15 and 6.7 points on four targets against the Rams in Week 17. It’s a cheap stack with a good floor, while the ceiling may be limited due to the Saints’ stingy secondary.

Shough is going to be stacked alongside WR Dante Pettis and RB Audric Estime. Injuries have gashed the Saints offense down the stretch, so Pettis should be able to build off 3-53 on four targets against the Titans in Week 17 with Olave sidelined.

Estime turned his 14 carries into 94 rushing yards and a touchdown against Tennessee last week. He’ll draw a favorable matchup against Atlanta’s 18th-ranked run defense, while also hauling in seven receptions on eight targets in his previous three starts.

Dallas Cowboys vs. New York Giants

We’re jumping into an NFC East classic rivalry matchup in the Meadowlands between the Cowboys and Giants for our next stacking opportunity. Oddsmakers expect a high-scoring affair with a 49.5 point total due to a pair of porous defenses and Dallas’ high-octane offense.

Dak Prescott will of course be tagged as our QB1. He’s going to be stacked with TE1 Jake Ferguson, who has stayed productive in fantasy despite a reduced target share.

Ferguson has a bottom-10 matchup against the Giants’ pass defense. He went for 9-78 on 12 targets during Dallas’ previous head-to-head matchup against the Giants.

Ryan Flournoy has been productive as Dallas’ WR3, and now, he draws a top-10 matchup against New York. Flournoy has two touchdowns in his last three games, while bouncing between two to nine receptions during his last four outings. He’s a boom-bust player with a high floor due to his effectiveness in the red zone.

The Giants’ offense found life again during their win over Las Vegas in Week 17. QB Jaxson Dart has the best fantasy quarterback matchup to close out his rookie season, so expect him to use his legs to rack up production as a ball carrier. Last week, he scored twice for 48 rushing yards, while throwing for over 200 yards.

Devin Singletary is my favorite Giants skilled player to stack with Dart. Singletary is relatively cheap and just logged four receptions for 25 yards on four targets, on top of 8-45-1 as a ball carrier against the Raiders. Dallas’ run defense is improved but still a vulnerable unit that gives up explosives, so plug Singletary in with Dart as a high-value stack at home against the Cowboys.

Tennessee Titans vs. Jacksonville Jaguars

The Titans will look to end their season on a high note with a win over the red-hot Jacksonville Jaguars on the road in Week 18. Tennessee is a top-10 matchup for fantasy quarterbacks, wideouts, and running backs, so we’ve got plenty of options to target on Jacksonville.

I’m bypassing Travis Etienne in favor of a pair of Jaguars wideouts. Yes, this is a run-centric offense, but head coach Liam Coen may want to build up Trevor Lawrence’s confidence in a plus-matchup ahead of the AFC playoffs.

Lawrence is a highly effective ball carrier, especially in the red zone, which gives him a huge floor. He’s been locked in on Jakobi Meyers, while Parker Washington also has logged double-digit targets in back-to-back starts as the Jaguars’ top target.

It’s been an ugly year for the Titans but Cam Ward has begun to rack up fantasy points later this season. The No. 1 overall draft pick has finished with 15-18 fantasy points in three straight starts for Tennessee, throwing for two touchdowns against the 49ers, Chiefs, and Saints.

Now, Ward should be able to stay productive against a Jacksonville defense that is more tailored to stop the run than the pass. Ward has been looking at WR Elic Ayomanor, throwing at his rookie wideout 11 times in their previous two games.

Ayomanor has finished with double-digit fantasy points in three starts, including Week 17 against the Saints. He’s a cheap commodity that holds a decent floor against the Jaguars’ 19th-ranked pass defense.

Matthew MacKay is a featured writer for BettingPros and FantasyPros. For more from Matthew, check out his archive and follow him @Matt_MacKay_.