| Player | BYE | TACKLE | ASSIST | SACK | PD | INT | FF | FR | TD | FPTS |
|---|---|---|---|---|---|---|---|---|---|---|
| Arvell Reese NYG | 8 | 81.7 | 42.0 | 2.0 | 4.2 | 0.9 | 1.0 | 0.9 | 0.1 | 181.5 |
| Maxx Crosby LV | 13 | 61.4 | 32.1 | 10.9 | 3.3 | 0.6 | 1.6 | 0.7 | 0.2 | 177.7 |
| Myles Garrett LAR | 11 | 51.3 | 20.3 | 15.1 | 0.7 | 0.0 | 2.8 | 0.8 | 0.1 | 168.9 |
| Brian Burns NYG | 8 | 52.3 | 27.0 | 11.4 | 5.8 | 0.2 | 2.2 | 1.3 | 0.1 | 168.7 |
| Jeffery Simmons TEN | 9 | 59.2 | 35.8 | 8.4 | 2.1 | 0.0 | 2.4 | 1.4 | 0.1 | 168.1 |
| Andrew Van Ginkel MIN | 6 | 58.8 | 29.7 | 6.5 | 8.5 | 0.9 | 0.8 | 0.7 | 0.1 | 160.2 |
| Aidan Hutchinson DET | 6 | 45.2 | 20.2 | 12.3 | 2.1 | 0.5 | 3.1 | 1.6 | 0.1 | 157.6 |
| Will Anderson Jr. HOU | 8 | 44.9 | 21.0 | 11.3 | 1.8 | 0.0 | 3.2 | 2.0 | 0.1 | 152.6 |
| Nick Bosa SF | 8 | 49.7 | 22.6 | 10.3 | 0.9 | 0.0 | 2.4 | 1.4 | 0.1 | 150.3 |
| T.J. Watt PIT | 9 | 47.3 | 25.8 | 8.0 | 5.3 | 0.7 | 2.3 | 1.4 | 0.1 | 149.3 |
PD = Passes Defended, FF = Forced Fumbles, FR = Fumbles Recovered, FPTS = Fantasy Points (based on Standard Scoring)
