| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 14.6 | 5.8 | 7.7 | 18.9 | 30.4 | 28.3 | 16.5 | 19.7 | 33 | 21.6 | 19.7 | 196.5 | ||||||||
| 2 | Derrick Henry | RB | BAL | 9.2 | 44.7 | 17.9 | 24.7 | 31 | 34.6 | 15.4 | 6.8 | - | - | 23 | 184.3 | ||||||||
| 3 | Austin Ekeler | RB | WAS | 11.7 | 18 | 19.7 | 28 | 30.4 | 7.5 | - | 21.4 | 9.7 | 13.4 | 17.8 | 159.8 | ||||||||
| 4 | Najee Harris | RB | LAC | 5.4 | 16.6 | 21.2 | 18.1 | 21.2 | 21.7 | BYE | 19.5 | 15.3 | 15.3 | 17.1 | 154.3 | ||||||||
| 5 | Joe Mixon | RB | HOU | 23 | 7.6 | 9.9 | 13.2 | 10 | 23.8 | 11.9 | 23.1 | 25.5 | BYE | 16.4 | 148 | ||||||||
| 6 | Ezekiel Elliott | RB | FA | 4.9 | 16.7 | 25.1 | 20.3 | 24.2 | 15.4 | - | 9.3 | 11.1 | 19.3 | 16.3 | 146.3 | ||||||||
| 7 | Aaron Jones Sr. | RB | MIN | 3.2 | 38.5 | 16.6 | 9.4 | 12.9 | 19 | 6.4 | 20.5 | 5.3 | 10.6 | 14.2 | 142.4 | ||||||||
| 8 | Alvin Kamara | RB | NO | 16.6 | 5 | 19.3 | 12 | 26.7 | BYE | 28.9 | 15.1 | 18.4 | - | 17.8 | 142 |