| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 31.9 | 28.8 | 18 | 21.2 | 34 | 24.6 | 26.4 | 158.5 | ||||||||||||
| 2 | Najee Harris | RB | LAC | 22.2 | 24.7 | BYE | 21 | 16.8 | 17.3 | 20.4 | 102 | ||||||||||||
| 3 | Joe Mixon | RB | HOU | 10.5 | 26.3 | 11.9 | 25.1 | 28 | BYE | 20.4 | 101.8 | ||||||||||||
| 4 | James Conner | RB | ARI | 10.7 | 8.1 | 12.4 | 14.2 | 40.3 | 15.4 | 16.9 | 101.1 | ||||||||||||
| 5 | Alvin Kamara | RB | NO | 29.2 | BYE | 33.9 | 16.6 | 20.4 | - | 25 | 100.1 | ||||||||||||
| 6 | Darrel Williams | RB | FA | 7.5 | 23.9 | 8 | 17 | 10.7 | 29.4 | 16.1 | 96.5 | ||||||||||||
| 7 | Leonard Fournette | RB | FA | 21 | 30.7 | 17 | 7.3 | - | 17.2 | 18.6 | 93.2 | ||||||||||||
| 8 | D'Andre Swift | RB | CHI | 22.4 | 17.7 | 28.4 | 8.1 | - | 16.5 | 18.6 | 93.1 |