| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 42.9 | 7.3 | 27.8 | 33.9 | 47.7 | 21.7 | - | 27.5 | 37.6 | 26.1 | 30.1 | 34.3 | 30.6 | 336.9 | |||||
| 2 | Dalvin Cook | RB | FA | 26 | 28.1 | 24.3 | 19 | 25.8 | 13.4 | 27.9 | 28.1 | 15.6 | 31.3 | 16.7 | - | 23.3 | 256.2 | |||||
| 3 | Austin Ekeler | RB | WAS | 39.4 | 23.3 | 15.1 | 29.2 | 22.3 | 5.8 | 25.5 | 10.2 | 13.3 | 12.8 | 21.2 | - | 19.8 | 218.1 | |||||
| 4 | Aaron Jones Sr. | RB | MIN | 4.9 | 25 | 15.3 | 17.8 | 49.2 | 8 | 18.3 | 41.6 | 3.9 | 27.3 | - | 3.8 | 19.6 | 215.1 | |||||
| 5 | Leonard Fournette | RB | FA | 11.4 | 12.7 | 15.2 | 26.5 | 23.7 | 17.8 | 16.5 | 20.6 | 12.2 | - | 12.7 | 36.9 | 18.7 | 206.2 | |||||
| 6 | Nick Chubb | RB | HOU | 11.5 | 19.8 | 17.1 | 39.3 | 10.9 | 28.9 | - | 10.8 | 13.1 | 14.1 | 9.2 | 25.4 | 18.2 | 200.1 | |||||
| 7 | Derrick Henry | RB | BAL | 28.9 | 17.4 | 11.6 | 11.8 | 13.8 | 4.3 | 17.8 | 7.3 | 24.9 | 33.1 | - | 28.5 | 18.1 | 199.4 | |||||
| 8 | Ezekiel Elliott | RB | FA | 13.3 | 20 | 15.9 | 16.5 | 17.1 | 26.3 | 26.7 | - | 13.9 | 8.3 | 19.3 | 16.6 | 17.6 | 193.9 |