| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Nick Chubb | RB | HOU | 32.3 | 17.3 | 20.7 | 23.4 | 70.3 | |||||||||||||||
| 2 | Austin Ekeler | RB | WAS | 18.4 | 13.3 | 34.9 | 22.2 | 66.6 | |||||||||||||||
| 3 | Josh Jacobs | RB | GB | 9.1 | 14.7 | 34.5 | 19.4 | 58.3 | |||||||||||||||
| 4 | Derrick Henry | RB | BAL | 8.5 | 25.3 | 23.7 | 19.2 | 57.5 | |||||||||||||||
| 5 | Christian McCaffrey | RB | SF | 16.8 | 13.5 | 25.8 | 18.7 | 56.1 | |||||||||||||||
| 6 | Jamaal Williams | RB | FA | 7 | 24.7 | 23.9 | 18.5 | 55.6 | |||||||||||||||
| 7 | Clyde Edwards-Helaire | RB | KC | 15.8 | 14.9 | 22.4 | 17.7 | 53.1 | |||||||||||||||
| 8 | Dameon Pierce | RB | KC | 8.7 | 18.1 | 25.9 | 17.6 | 52.7 |