| # | Player | Pos | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | AVG | TTL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Joe Mixon | RB | HOU | 51.1 | - | 6.2 | 28.7 | 57.3 | |||||||||||||||
| 2 | Derrick Henry | RB | BAL | 23.5 | 6.7 | 23.4 | 17.9 | 53.6 | |||||||||||||||
| 3 | Tony Pollard | RB | TEN | - | 18.8 | 30.9 | 24.9 | 49.7 | |||||||||||||||
| 4 | Jamaal Williams | RB | FA | 10.1 | 11.9 | 24.4 | 15.5 | 46.4 | |||||||||||||||
| 5 | Josh Jacobs | RB | GB | 8.7 | 16.6 | 16 | 13.8 | 41.3 | |||||||||||||||
| 6 | Austin Ekeler | RB | WAS | 17.1 | 6.3 | 16 | 13.1 | 39.4 | |||||||||||||||
| 7 | Dalvin Cook | RB | FA | 11.6 | 20.6 | 7.2 | 13.1 | 39.4 | |||||||||||||||
| 8 | James Conner | RB | ARI | 6.4 | 20.6 | 11.4 | 12.8 | 38.4 |